The chronic effects of agronomic xenobiotic agents on the health or lifespan of ecosystem organisms and humans have not been clearly identified. In particular, staple grains such as rice and wheat are contaminated with mycotoxins and antibiotics at very low concentrations. In particular, the low dose chronic exposure during the human life span is not well documented. 

 The research team predicted how small amounts of agronomic xenobiotic factors released during crop production would affect nematodes, which form the largest biomass in the soil biosystem, and ultimately humans. In particular, changes in intestinal flora and consequent increase in inflammation along with aging aggravated the damage of digestive immunity. When predicted through human aging big data, it was confirmed that gut defense disruption caused by these toxic stresses is compromised. In conclusion, we revealed the threat to one health in environmental life-livestock-human by the contaminated food chain.

 In conclusion, crop contamination-associated food chain from the farm to the table causes damage to the aging gut defense of environmental organisms, livestock, and humans, which presents important evidence of One Health that threatens global bioshere.

Crop contaminants including mycotoxins and antibiotics generated during the crop production are released into soil and aquatic environments and are exposed through the ecosystem, leading to detrioration of aging gut defense in the biological systems

[Reference] Sun J. et al., (2023) “SXenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective” RedoX Biology

[Main Author] Sun Junjie (Pusan national university)

* Contact email : Professor Yuseok Moon (moon@pnu.edu)