A research team (Professor Jungmok Seo (Yonsei University) and Professor Donghee Son (Sungkyunkwan University)) has developed an artificial blood vessels that resolve concerns regarding thrombus formation and immune-related complications after surgery. The study is publisehd in ACS Nano on April, 2023.

The developed Resealable antithrombotic artificial vascular graft (RAAVG) is made of tough self-healing polymer (T-SHP) and slippery lubricant coating. with self-healing properties and a slippery mucous coating. T-SHP has high mechanical durability and self-healing properties to withstand mechanical stimuli as a blood vessel. The slippery lubricant coating endows T-SHP anti-biofouling properties which allow it to prevent attachment of immune-related biosubstances and thrombosis during the blood flow. Furthermore, biocompatibility of RAAVG was confirmed via mouse model that RAAVG can be attached to blood vessel without leakages or adverse immune responses. 

The research team plans to conduct subsequent studies on the applicability of the proposed self-healing anti-thrombotic material to various electronic drug and bioelectronic applications in an expectation to solve various side effects occurring in implantable biomaterials.

Resealable antithrombotic artificial vascular graft (RAAVG) with multi-functionalities and integrated self-healing blood flow sensor

[Reference] Park K. et al., (2023) “Resealable Antithrombotic Artificial Vascular Graft Integrated with a Self-Healing Blood Flow Sensor” ACS Nano, 10.1021/acsnano.2c10657

[Main Author] First author Kijun Park (Yonsei University), Soojung An (Sungkyunkwan University), Jihyun Kim (Yonsei University)

Corresponding author Jungmok Seo (Yonsei University), Donghee Son (Sungkyunkwan University)

* Contact email : Professor Jungmok Seo (jungmok.seo@yonsei.ac.kr)